circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circ-ITCH
Host Gene: hsa-miR-214
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-214
Biological function: upregulation of circ-ITCH markedly inhibited NPC cell proliferation, migration and invasion
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ-ITCH suppressed NPC tumorigenesis by upregulating PTEN expression through interacting with miR-214, thus proposing a novel mechanism for NPC inhibition.
Other information
Title:

Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR-214.

Journal: J Gene Med
Published: 2021/10/7
PubMed ID: 34612550