circRNA basic information
circBase ID: hsa_circ_0005273
Name: hsa_circ_PTK2
Synonym: CircPTK2
Host Gene: hsa-miR-196a-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: AATK
Associated microRNA: hsa-miR-196a-3p
Biological function: Upregulation of circPTK2 significantly suppressed the proliferation, migration, and invasion of gastric cancer cells, while circPTK2 knockdown exhibited opposite effects.
Molecular mechanism: circPTK2 could competitively bind to hsa-miR-196a-3p and prevent hsa-miR-196a-3p to reduce the expression of AATK
Survival: -
Supported No.:
 1
Description:

circPTK2 functions as a tumor suppressor to suppress gastric cancer cell proliferation, migration, and invasion through regulating the miR-196a-3p/AATK axis, suggesting that circPTK2 may serve as a novel therapeutic target for gastric cancer.
Other information
Title:

CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis.

Journal: Front Oncol
Published: 2021/10/5
PubMed ID: 34604044