circRNA basic information
circBase ID: hsa_circ_0001598
Name: hsa_circ_DEF6
Synonym: -
Host Gene: hsa-miR-1184
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: hsa-miR-1184
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circ_0001598/miR-1184/PD-L1 signaling plays a crucial role in the regulation of BC progression and trastuzumab-resistance phonotypes, which suggests that circ_0001598 may be a molecular target to treat HER2-positive BC patients.
Other information
Title:

Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells.

Journal: Immunol Res
Published: 2021/9/25
PubMed ID: 34559381