circRNA basic information
circBase ID: hsa_circ_0006404
Name: hsa_circ_FOXO3
Synonym: circ_FOXO3
Host Gene: hsa-miR-543
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CRC cell lines (HT29, HCT116, HCT8, LOVO, SW480, SW620), wild-type colon epithelial cell line (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: LATS1
Associated microRNA: hsa-miR-543
Biological function: circ_FOXO3 overexpression suppressed CRC cell proliferation, migration and invasion
Molecular mechanism: circ_FOXO3 increased the expression of LATS1 via sponging miR_543
Survival: better
Supported No.:
 1
Description:

circ_FOXO3 inhibited CRC metastasis and progression via elevated LATS1 expression by sponging miR_543. Therefore, circ_FOXO3 may be a promising target for CRC therapy.
Other information
Title:

Identification of the tumor_suppressive role of circular RNA_FOXO3 in colorectal cancer via regulation of miR_543/LATS1 axis.

Journal: Oncol Rep
Published: 2021/9/23
PubMed ID: 34549306