circRNA basic information
circBase ID: -
Name: hsa_circ_UBXN7
Synonym: circUBXN7
Host Gene: hsa-miR-622
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: acute myocardial infarction
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: H9c2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MCL1
Associated microRNA: hsa-miR-622
Biological function: Overexpression of circUBXN7 mitigated H/R-mediated apoptosis and secretion of inflammatory factors including IL-6, TNF-¦Á and IL-1beta.
Molecular mechanism: CircUBXN7 suppressed cell apoptosis and inflammatory reaction induced by H/R via targeting miR-622. MiR-622 targeted MCL1 to restrain its expression in H9c2 cells.
Survival: -
Supported No.:
 2
Description:

CircUBXN7 mitigates cardiomyocyte apoptosis and inflammatory reaction in H/R injury by targeting miR-622 and maintaining MCL1 expression. Our study provides novel potential therapeutic targets for AMI treatment.
Other information
Title:

CircUBXN7 mitigates H/R-induced cell apoptosis and inflammatory response through the miR-622-MCL1 axis.

Journal: Am J Transl Res
Published: 2021/9/21
PubMed ID: 34539989