circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: circNFIX
Host Gene: hsa-miR-3064-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-3064-5p
Biological function: Knockdown of circNFIX repressed proliferation, invasion and glutaminolysis of HCC cells.
Molecular mechanism: circNFIX directly sponged hsa-miR-3064-5p to release HMGA2 expression, and thus conferred the malignant development of HCC
Survival: poor
Supported No.:
 1
Description:

circNFIX serves as a competing endogenous RNA to accelerate HCC progression via regulating miR-3064-5p/HMGA2 axis, suggesting a therapeutic strategy for HCC intervention.
Other information
Title:

circNFIX facilitates hepatocellular carcinoma progression by targeting miR-3064-5p/HMGA2 to enhance glutaminolysis.

Journal: Am J Transl Res
Published: 2021/9/21
PubMed ID: 34539988