circRNA basic information
circBase ID: hsa_circ_0015278
Name: -
Synonym: Circ_0015278
Host Gene: hsa-miR-1278
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS6
Associated microRNA: hsa-miR-1278
Biological function: Overexpression of circ_0015278 restrained the proliferation, colony formation, invasion, and epithelial-mesenchymal transition (EMT) of NSCLC cells and induced NSCLC cell apoptosis
Molecular mechanism: circ_0015278 acted as an hsa-miR-1278 sponge to reduce its quantity, and hsa-miR-1278 targeted SOCS6 to inhibit its expression in NSCLC cells
Survival: better
Supported No.:
 1
Description:

circ_0015278 attenuated the progression of NSCLC via targeting the miR-1278/SOCS6 axis, which provides potential diagnostic biomarkers and therapeutic targets.
Other information
Title:

Circular RNA _0015278 inhibits the progression of non-small cell lung cancer through regulating the microRNA 1278/SOCS6 gene axis.

Journal: Ann Transl Med
Published: 2021/9/18
PubMed ID: 34532392