circRNA basic information
circBase ID: -
Name: hsa_circ_PUM1
Synonym: circPUM1
Host Gene: hsa-miR-30a-5p
 
 
 
Disease basic information
DO ID:
 229
DO name: female reproductive system disease
Disease details: Recurrent spontaneous abortion
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: trophoblast cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: JUNB
Associated microRNA: hsa-miR-30a-5p
Biological function: CircPUM1 knockdown induced decreased proliferation, migration, and invasion, but increased apoptosis, pro-apoptotic protein (cleaved caspases-3) level, and proinflammatory factor (TNF-¦Á, IL-6, and IL-8) secretion in trophoblast cells
Molecular mechanism: _ircPUM1 was a sponge for miR-30a-5p, and JUNB was directly targeted by miR-30a-5p.
Survival: -
Supported No.:
 1
Description:

circPUM1 could impair RSA occurrence and development by facilitating trophoblast cellular processes and protecting against inflammation via the miR-30a-5p/JUNB axis, providing a new target for the improvement of RSA diagnosis and treatment.
Other information
Title:

Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis.

Journal: Bioengineered
Published: 2021/9/15
PubMed ID: 34519628