circRNA basic information
circBase ID: hsa_circ_0089153
Name: -
Synonym: circ_0089153
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal colonic epithelial cells (FHC), CRC cells (HCT116, SW480), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SENP1
Associated microRNA: hsa-miR-198
Biological function: Depletion of circ_0089153 repressed cell proliferation, sphere formation ability, and enhanced cell apoptosis, as well as inhibited tube formation in vitro
Molecular mechanism: circ_0089153 targeted hsa-miR-198, and the effects of circ_0089153 were mediated by hsa-miR-198
Survival: -
Supported No.:
 1
Description:

circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC.
Other information
Title:

Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis.

Journal: Bioengineered
Published: 2021/9/14
PubMed ID: 34516314