circRNA basic information
circBase ID: hsa_circ_0050898
Name: hsa_circ_ACTN4
Synonym: circACTN4
Host Gene: hsa-miR-424-5p
 
 
 
Disease basic information
DO ID:
 4928
DO name: intrahepatic cholangiocarcinoma
Disease details: Intrahepatic cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: hsa-miR-424-5p
Biological function: enhanced tumor proliferation and metastasis
Molecular mechanism: circACTN4 upregulated Yes-associated protein 1 (YAP1) expression by sponging hsa-miR-424-5p
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0050898, which originated from exon 1 to exon 20 of the ACTN4 gene (named circACTN4), was significantly upregulated in ICC. High circACTN4 expression was associated with enhanced tumor proliferation and metastasis in vitro and in vivo, as well as a worse prognosis following ICC resection.
Other information
Title:

Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription.

Journal: J Hepatol
Published: 2021/9/13
PubMed ID: 34509526