circRNA basic information
circBase ID: hsa_circ_0038467
Name: hsa_circ_UQCRC2
Synonym: circ-UQCRC2
Host Gene: hsa-miR-495-3p
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: cell line
Sample type details: 16HBE
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYD88
Associated microRNA: hsa-miR-495-3p
Biological function: Circ-UQCRC2 absence attenuated LPS-induced injury in 16HBE cells.
Molecular mechanism: miR-495-3p was a target of circ-UQCRC2, and circ-UQCRC2 silencing-mediated protective effects in LPS-induced 16HBE cells were partly reversed by anti-miR-495-3p. MYD88 was a target of miR-495-3p, and MYD88 overexpression partly counteracted miR-495-3p accumulation-mediated influences in 16HBE cells upon LPS exposure.
Survival: -
Supported No.:
 4
Description:

In conclusion, circ-UQCRC2 contributed to LPS-induced injury of 16HBE cells by targeting miR-495-3p/MYD88 signalling-mediated inflammatory response and oxidative stress.
Other information
Title:

Circ-UQCRC2 aggravates lipopolysaccharide-induced injury in human bronchial epithelioid cells via targeting miR-495-3p/MYD88-mediated inflammatory response and oxidative stress.

Journal: Autoimmunity
Published: 2021/9/10
PubMed ID: 34499003