circRNA basic information
circBase ID: -
Name: hsa_circ_MYH9
Synonym: CircMYH9
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: p53
Associated microRNA: -
Biological function: -
Molecular mechanism: circMYH9 destabilized the pre-mRNA of p53 by recruiting hnRNPA2B1 in the nucleus.
Survival: poor
Supported No.:
 1
Description:

The overexpression of circMYH9 promotes CRC proliferation though modulating serine/glycine metabolism and redox homeostasis in a p53-dependent manner, and targeting circMYH9 and its pathway may be an effective strategy for the treatment of CRC.
Other information
Title:

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Journal: Mol Cancer
Published: 2021/9/10
PubMed ID: 34496888