circRNA basic information
circBase ID: -
Name: hsa_circ_RNF111
Synonym: circRNF111
Host Gene: hsa-miR-143-3p
 
 
 
Disease basic information
DO ID:
 3146
DO name: lipid metabolism disorder
Disease details: Metabolic Syndrome
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human adipose-derived stem cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: IGF2R
Associated microRNA: hsa-miR-143-3p
Biological function: Loss-of-function experiments showed that circRNF111 knockdown inhibited the glucose uptake and the Akt signaling pathway, meanwhile increased the deposition of triglycerides in adipogenic differentiated hADSCs
Molecular mechanism: circRNF111 sponged miR-143-3p and functioned via targeting miR-143-3p along with its downstream target gene IGF2R
Survival: -
Supported No.:
 1
Description:

CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR-143-3p-IGF2R cascade. This provides a promising therapeutic approach for MetS.
Other information
Title:

CircRNF111 Protects Against Insulin Resistance and Lipid Deposition via Regulating miR-143-3p/IGF2R Axis in Metabolic Syndrome.

Journal: Front Cell Dev Biol
Published: 2021/9/7
PubMed ID: 34485272