circRNA basic information
circBase ID: -
Name: hsa_circ_E2F3
Synonym: Circ-E2F3
Host Gene: hsa-miR-296-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-296-5p
Biological function: circ-E2F3 promoted the proliferation, invasion, and migration of CC cells and tumor growth in vivo
Molecular mechanism: circ-E2F3 promoted the nuclear translocation of STAT3 through inhibition of hsa-miR-296-5p, thus affecting the expression of cyclin D1
Survival: poor
Supported No.:
 1
Description:

circ-E2F3 induces inhibition of miR-296-5p, which triggers activation and nuclear translocation of STAT3 that then upregulates cyclin D1 expression.
Other information
Title:

Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation.

Journal: Ann N Y Acad Sci
Published: 2021/9/2
PubMed ID: 34468993