circRNA basic information
circBase ID: hsa_circ_0007334
Name: -
Synonym: circ_0007334
Host Gene: hsa-miR-577
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF12
Associated microRNA: hsa-miR-577
Biological function: Circ_0007334 deficiency repressed cell viability, colony formation, migration, invasion, and angiogenesis in CRC cells
Molecular mechanism: circ_0007334 could regulate KLF12 expression by sponging hsa-miR-577
Survival: -
Supported No.:
 1
Description:

circ_0007334 deficiency exerts a tumor-suppressor by the miR-577/KLF12 axis in CRC, and indicated that exosomal circ_0007334 could hinder CRC tumor growth and angiogenesis in vivo.
Other information
Title:

Circular noncoding RNA circ_0007334 sequestrates miR-577 to derepress KLF12 and accelerate colorectal cancer progression.

Journal: Anticancer Drugs
Published: 2021/8/31
PubMed ID: 34459455