circRNA basic information
circBase ID: hsa_circ_0000384
Name: hsa_circ_MRPS35
Synonym: circMRPS35
Host Gene: hsa-miR-148a
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human 293T cells, human HCC cell lines (HepG2, SNU-398, SMMC-7721, Huh-7, HCC-LM3), human normal liver cell line (L02)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: STX3
Associated microRNA: hsa-miR-148a
Biological function: knockdown of the expression of circMRPS35 in Huh-7 and HCC-LM3 cells suppressed their proliferation, migration, invasion, clone formation, and cell cycle in vitro, and it suppressed tumor growth in vivo as well
Molecular mechanism: circMRPS35 sponged microRNA-148a-3p (hsa-miR-148a), regulating the expression of Syntaxin 3 (STX3), which modulated the ubiquitination and degradation of phosphatase and tensin homolog (PTEN).
Survival: -
Supported No.:
 1
Description:

knockdown of the expression of circMRPS35 in Huh-7 and HCC-LM3 cells suppressed their proliferation, migration, invasion, clone formation, and cell cycle in vitro, and it suppressed tumor growth in vivo as well. Mechanically, circMRPS35 sponged microRNA-148a-3p (miR-148a), regulating the expression of Syntaxin 3 (STX3), which modulated the ubiquitination and degradation of phosphatase and tensin homolog (PTEN).
Other information
Title:

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma.

Journal: Mol Ther
Published: 2021/8/28
PubMed ID: 34450251