Detected method: |
Q
|
Detected method confidence |
High
|
Expression pattern: |
|
Associated gene: |
Pdk1 |
Associated microRNA: |
hsa-miR-146a-5p |
Biological function: |
LPS exposure reduced cell viability and promoted cell apoptosis and inflammatory response partly by upregulating circ_RASGEF1B. |
Molecular mechanism: |
Circ_RASGEF1B bound to miR-146a-5p and miR-146a-5p interference partly overturned circ_RASGEF1B silencing-mediated effects in LPS-induced TCMK-1 cells. Pdk1 was a target of miR-146a-5p, and Pdk1 accumulation partly counteracted miR-146a-5p-induced influences in TCMK-1 cells upon LPS stimulation. |
Survival: |
- |
Supported
No.: |
1 |
Description: |
Circ_RASGEF1B promoted LPS-induced apoptosis and inflammatory response in renal tubular epithelial cells partly by upregulating Pdk1 via acting as miR-146a-5p sponge. |