circRNA basic information
circBase ID: hsa_circ_0026628
Name: hsa_circ_SP1
Synonym: circ_0026628
Host Gene: hsa-miR-346
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colorectal mucosal cell line (FHC), 4 human CRC cell lines (SW620, LOVO, SW480, SW116) were used for study
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: Wnt/beta-catenin pathway
Associated microRNA: hsa-miR-346
Biological function: circ_0026628 functioned as a contributor to CRC cell proliferation, migration, EMT, and stemness
Molecular mechanism: circ_0026628 served as the endogenous sponge of hsa-miR-346 and FUS to elevate SP1 expression at the post-transcriptional level, thus strengthening the interaction between SP1 and beta-catenin to activate the Wnt/beta-catenin pathway. In turn, the downstream gene of Wnt/beta-catenin signaling, SOX2 (SRY-box transcription factor 2), transcriptionally activated SP1 and therefore boosted circ_0026628 level.
Survival: -
Supported No.:
 1
Description:

SOX2-induced circ_0026628 sponged miR-346 and recruited FUS protein to augment SP1, triggering the downstream Wnt/beta-catenin pathway to facilitate CRC progression.
Other information
Title:

Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/beta-catenin pathway.

Journal: Cell Death Dis
Published: 2021/8/23
PubMed ID: 34420031