circRNA basic information
circBase ID: hsa_circ_0019853
Name: hsa_circ_PDCD11
Synonym: circPDCD11
Host Gene: hsa-miR-432-5p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: TNBC cell lines (BT549, MDA-MB-468, MDA-MB-231), human normal breast cells (MCF10A)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: LDHA
Associated microRNA: hsa-miR-432-5p
Biological function: circPDCD11 accelerated glucose uptake, lactate production, ATP generation, and the extracellular acidification rate in TNBC cells
Molecular mechanism: circPDCD11 acted as a miRNA sponge to enhance LDHA expression by sponging hsa-miR-432-5p
Survival: poor
Supported No.:
 1
Description:

CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis.
Other information
Title:

CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis.

Journal: Cell Death Discov
Published: 2021/8/23
PubMed ID: 34420029