circRNA basic information
circBase ID: hsa_circ_0027089
Name: -
Synonym: Circ_0027089
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatitis B virus-related hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NACC1
Associated microRNA: hsa-miR-136-5p
Biological function: circ_0027089 knockdown inhibited HepG2.2.15 and HepAD38 (tet-off) cell proliferation, migration and invasion but induced cell cycle arrest and apoptosis, while circ_0027089 overexpression played the reversed effects
Molecular mechanism: by regulating NACC1 via competitively targeting hsa-miR-136-5p
Survival: -
Supported No.:
 2
Description:

Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR-136-5p.
Other information
Title:

Circ_0027089 regulates NACC1 by targeting miR-136-5p to aggravate the development of hepatitis B virus-related hepatocellular carcinoma.

Journal: Anticancer Drugs
Published: 2021/8/23
PubMed ID: 34419960