circRNA basic information
circBase ID: hsa_circ_0079587
Name: hsa_circ_IGF2BP3
Synonym: circIGF2BP3
Host Gene: hsa-miR-328-3p, hsa-miR-3173-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T cells, human LUAD cells (A549, NCI-H1650, NCI-H1975), human LUSC cells (SW900, SK-MES-1, NCI-H1703, NCI-H520), a normal lung epithelial cell line (BEAS-2B), a bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: OTUB1
Associated microRNA: hsa-miR-328-3p, hsa-miR-3173-5p
Biological function: elevated circIGF2BP3 inactivated cocultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model, and this effect was dependent on CD8(+) T cells
Molecular mechanism: METTL3 mediates the N(6)-methyladenosine (m(6)A) modification of circIGF2BP3 and promotes its circularization in a manner dependent on the m(6)A reader protein YTHDC1. circIGF2BP3 competitively upregulates PKP3 expression by sponging hsa-miR-328-3p and hsa-miR-3173-5p to compromise the cancer immune response.
Survival: -
Supported No.:
 1
Description:

Our results reveal the function of circIGF2BP3 in causing immune escape from CD8(+) T cell-mediated killing through a decrease in PD-L1 ubiquitination and subsequent proteasomal degradation by stabilizing OTUB1 mRNA in a PKP3-dependent manner.

Other information
Title:

N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer.

Journal: Mol Cancer
Published: 2021/8/22
PubMed ID: 34416901