circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-17-5p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: sepsis
Species: human
Species details: human
Sample type: cell line
Sample type details: cardiomyocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PARP1
Associated microRNA: hsa-miR-17-5p
Biological function: circTLK1 knockdown repressed sepsis-induced mtDNA oxidative damage, mitochondrial dysfunction and consequent cardiomyocyte apoptosis by inhibiting PARP1/HMGB1 axis in vitro and in vivo.
Molecular mechanism: circTLK1 enhanced PARP1 expression via sponging miR-17-5p
Survival: -
Supported No.:
 1
Description:

CircTLK1 sponged miR-17-5p to aggravate mtDNA oxidative damage, mitochondrial dysfunction and cardiomyocyte apoptosis via activating PARP1/HMGB1 axis during sepsis, indicating that circTLK1 may be a putative therapeutic target for septic cardiomyopathy.
Other information
Title:

CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.

Journal: J Cell Mol Med
Published: 2021/8/20
PubMed ID: 34410682