circRNA basic information
circBase ID: hsa_circ_0003732
Name: -
Synonym: Circ_0003732
Host Gene: hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CPEB1
Associated microRNA: hsa-miR-377-3p
Biological function: Knockdown of circ_0003732 suppressed osteosarcoma cell proliferation, migration, invasion and triggered cell apoptosis in vitro, as well as reduced osteosarcoma tumor growth in vivo.
Molecular mechanism: silence restrained Wnt/beta-catenin signaling pathway via regulating hsa-miR-377-3p
Survival: -
Supported No.:
 2
Description:

Circ_0003732 might play a positive role in the malignant progression of osteosarcoma by regulating the miR-377-3p/CPEB1 axis and activating the Wnt/beta-catenin signaling pathway, which might provide new insights for osteosarcoma therapy.
Other information
Title:

Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/beta-catenin signaling pathway.

Journal: Anticancer Drugs
Published: 2021/8/19
PubMed ID: 34407049