circRNA basic information
circBase ID: hsa_circ_0018289
Name: -
Synonym: circ_0018289
Host Gene: hsa-miR-183-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TMED5
Associated microRNA: hsa-miR-183-5p
Biological function: Circ_0018289 silencing impeded cell proliferation, enhanced cell apoptosis, and suppressed angiogenesis in vitro, as well as diminished tumor growth in vivo
Molecular mechanism: circ_0018289 induced TMED5 expression by competitively binding to shared hsa-miR-183-5p
Survival: -
Supported No.:
 3
Description:

TMED5 was directly targeted and inhibited by miR-183-5p through the perfect complementary sites in TMED5 3UTR, and TMED5 knockdown phenocopied miR-183-5p overexpression in suppressing cervical cancer development and angiogenesis. Furthermore, circ_0018289 induced TMED5 expression by competitively binding to shared miR-183-5p.
Other information
Title:

Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development.

Journal: World J Surg Oncol
Published: 2021/8/19
PubMed ID: 34404391