circRNA basic information
circBase ID: hsa_circ_0007766
Name: hsa_circ_ERBB2
Synonym: circ-ERBB2
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDK4
Associated microRNA: hsa-miR-136-5p
Biological function: circ-ERBB2 knockdown constrained TNBC growth in vivo, reduced the Warburg effect, accelerated apoptosis, and repressed the proliferation, migration, and invasion of TNBC cells in vitro
Molecular mechanism: circ-ERBB2 sponged microRNA 136-5p (hsa-miR-136-5p) to elevate pyruvate dehydrogenase kinase 4 (PDK4) expression
Survival: poor
Supported No.:
 1
Description:

circ-ERBB2 facilitated the Warburg effect and malignancy of TNBC cells by the miR-136-5p/PDK4 pathway, at least in part.
Other information
Title:

Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis.

Journal: Mol Cell Biol
Published: 2021/8/10
PubMed ID: 34370552