circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-30a-3p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: retinal vascular dysfunction
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: factor-C, FZD4, and WNT2
Associated microRNA: hsa-miR-30a-3p
Biological function: -
Molecular mechanism: acted as an endogenous hsa-miR-30a-3p sponge to sequester and inhibit hsa-miR-30a-3p activity, which led to increased vascular endothelial growth factor-C, FZD4, and WNT2 expression
Survival: -
Supported No.:
 1
Description:

The circular RNA circHIPK3 plays a role in diabetic retinopathy by blocking miR-30a function, leading to increased endothelial proliferation and vascular dysfunction. These data suggest that circular RNA is a potential target to control diabetic proliferative retinopathy.
Other information
Title:

Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.

Journal: Circulation
Published: 2017/9/2
PubMed ID: 28860123