circRNA basic information
circBase ID: hsa_circ_0011946
Name: hsa_circ_SCMH1
Synonym: circ-SCMH1
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SCC-15/DDP, CAL-27/DDP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LIN28B
Associated microRNA: hsa-miR-338-3p
Biological function: Circ-SCMH1 knockdown suppressed the half-maximal inhibitory concentration of DDP, colony formation, and migration/invasion in SCC-15/DDP and CAL-27/DDP cells, but promoted apoptosis rate and apoptotic proteins (Bax and cleaved-caspase-3) expression
Molecular mechanism: circ-SCMH1 directly sponged hsa-miR-338-3p in regulating LIN28B, a target gene for hsa-miR-338-3p
Survival: -
Supported No.:
 3
Description:

Circ-SCMH1 contributes to chemoresistance of DDP-resistant OSCC cells partially via EVs secretion and circ-SCMH1/miR-338-3p/LIN28B axis.
Other information
Title:

Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B.

Journal: Cancer Cell Int
Published: 2021/8/7
PubMed ID: 34353342