circRNA basic information
circBase ID: -
Name: hsa_circ_EGFR
Synonym: circEGFR
Host Gene: hsa-miR-106a-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX5/AKT
Associated microRNA: hsa-miR-106a-5p
Biological function: circEGFR promoted CRC cell proliferation, migration, and invasion
Molecular mechanism: enhanced DDX5 expression, thereby upregulating p-AKT levels
Survival: poor
Supported No.:
 1
Description:

circEGFR promoted CRC cell proliferation, migration, and invasion through the miR-106a-5p/DDX5/AKT axis, and may serve as a promising diagnostic marker and therapeutic target for CRC patients.
Other information
Title:

Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer.

Journal: Braz J Med Biol Res
Published: 2021/7/29
PubMed ID: 34320120