circRNA basic information
circBase ID: -
Name: hsa_circ_WHSC1
Synonym: circWHSC1
Host Gene: hsa-miR-296-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT3
Associated microRNA: hsa-miR-296-3p
Biological function: CircWHSC1 silence significantly inhibited colony formation, viability, invasion, and migration, while increased NSCLC cell apoptosis
Molecular mechanism: functions as a ceRNA of hsa-miR-296-3p to up-regulate AKT3
Survival: poor
Supported No.:
 3
Description:

CircWHSC1 is an independent indicator of poor prognosis in NSCLC patients, and functions as a ceRNA of miR-296-3p to up-regulate AKT3, consequently promotes NSCLC cell growth and metastasis. Targeting circWHSC1 might be a prospective strategy for diagnosis, therapeutics, and prognosis of NSCLC.
Other information
Title:

CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.

Journal: J Clin Lab Anal
Published: 2021/7/28
PubMed ID: 34313353