circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: CircPVT1
Host Gene: hsa-miR-339-3p
 
 
 
Disease basic information
DO ID:
 3121
DO name: gallbladder cancer
Disease details: gallbladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GBC cell lines (GBC-SD, EHGB-1, SGC-996, NOZ), normal biliary epithelia cell line (HIBEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MCL-1
Associated microRNA: hsa-miR-339-3p
Biological function: knockdown of circPVT1 significantly impeded GBC cell proliferation, migration, invasion, while induced cell apoptosis in vitro
Molecular mechanism: circPVT1 could regulate Myeloid cell leukemia-1 (MCL-1) expression by sponging to hsa-miR-339-3p
Survival: poor
Supported No.:
 1
Description:

circPVT1 could regulate Myeloid cell leukemia-1 (MCL-1) expression by sponging to miR-339-3p, which affected tumor progression in GBC cells.
Other information
Title:

CircPVT1 promotes gallbladder cancer growth by sponging miR-339-3p and regulates MCL-1 expression.

Journal: Cell Death Discov
Published: 2021/7/28
PubMed ID: 34312371