circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW7
Synonym: circFBXW7
Host Gene: hsa-miR-942
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RCC cell lines (A498, 786O), normal cells (HK2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-942
Biological function: Propofol alleviated cell proliferation, migration, invasion, and induced apoptosis in vitro and impeded tumor growth in vivo in ccRCC. Propofol elevated the level of circFBXW7, which knockdown reversed the anticancer effects of propofol on ccRCC cell tumorigenesis.
Molecular mechanism: CircFBXW7 directly bound to hsa-miR-942, and suppressed ccRCC cell malignant biological behaviors via targeting hsa-miR-942. Besides that, propofol decreased hsa-miR-942 expression, and hsa-miR-942 overexpression attenuated the effects of propofol on ccRCC cells. Moreover, propofol could regulate hsa-miR-942 expression through circFBXW7.
Survival: -
Supported No.:
 2
Description:

Propofol suppressed the growth, migration, and invasion of ccRCC cells by regulating circFBXW7/miR-942 axis, suggesting a potential therapeutic strategy for the intervention of human ccRCC development.
Other information
Title:

Propofol Disrupts Clear Cell Renal Cell Carcinoma Tumorigenesis by Regulating circFBXW7/miR-942 Axis.

Journal: Nephron
Published: 2022/3/22
PubMed ID: 35307709