circRNA basic information
circBase ID: -
Name: hsa_circ_MAT2B
Synonym: circMAT2B
Host Gene: hsa-miR-431
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-431
Biological function: circMAT2B knockdown markedly inhibited the proliferation, migration, invasion and EMT
Molecular mechanism: circMAT2B could directly interact with hsa-miR-431, and subsequently decrease hsa-miR-431 expression in NSCLC
Survival: poor
Supported No.:
 1
Description:

Further functional experiments showed that circMAT2B knockdown markedly inhibited the proliferation, migration, invasion and EMT of NSCLC cells, whereas circMAT2B overexpression led to the opposing results. Mechanistically, circMAT2B could directly interact with miR-431, and subsequently decrease miR-431 expression in NSCLC. The effects of circMAT2B overexpression in NSCLC cells were abrogated by miR-431 restoration.
Other information
Title:

Circular RNA MAT2B promotes migration, invasion and epithelial-mesenchymal transition of non-small cell lung cancer cells by sponging miR-431.

Journal: Cell Cycle
Published: 2021/7/22
PubMed ID: 34288814