circRNA basic information
circBase ID: hsa_circ_0009154
Name: hsa_circ_UBE2K
Synonym: circUBE2K
Host Gene: hsa-miR-516b-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: bladder transitional cell carcinoma cell lines (RT4, UM-UC-3, T24, 5637, J82)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: ARHGAP5/RhoA axis
Associated microRNA: hsa-miR-516b-5p
Biological function: down-regulating circUBE2K decreased BC cell phenotype as proliferation, invasion, and migration, respectively
Molecular mechanism: circUBE2K promoted BC progression via sponging hsa-miR-516b-5p and enhancing ARHGAP5 expression through regulating RhoA activity
Survival: -
Supported No.:
 1
Description:

circUBE2K is a tumor-promoting circRNA in BC that functions as a ceRNA to regulate ARHGAP5 expression via sponging miR-516b-5p.
Other information
Title:

High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis.

Journal: Cell Death Dis
Published: 2021/7/22
PubMed ID: 34285193