circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: circ-PRKCI
Host Gene: hsa-miR-106b-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: cell line
Sample type details: HK-2 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: GAB1
Associated microRNA: hsa-miR-106b-5p
Biological function: Circ-PRKCI overexpression abrogated the effects of LPS on cell apoptosis, inflammation, and oxidative stress in HK-2 cells.
Molecular mechanism: circ-PRKCI was identified as the sponge for miR-106b-5p to positively regulate GAB1 expression.
Survival: -
Supported No.:
 1
Description:

Collectively, Circ-PRKCI overexpression attenuated LPS-induced HK-2 cell injury by regulating miR-106b-5p/GAB1 axis.
Other information
Title:

Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis.

Journal: J Cardiovasc Pharmacol
Published: 2021/7/17
PubMed ID: 34269703