circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: hsa-miR-615-5p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: vascular endothelial dysfunction
Species: human
Species details: human
Sample type: cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MEF2A
Associated microRNA: hsa-miR-615-5p
Biological function: cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro.
Molecular mechanism: inhibit hsa-miR-615-5p activity, which led to increased MEF2A expression
Survival: -
Supported No.:
 1
Description:

cZNF609 was significantly up-regulated upon high glucose and hypoxia stress in vivo and in vitro. cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro.
Other information
Title:

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.

Journal: Theranostics
Published: 2017/8/22
PubMed ID: 28824721