circRNA basic information
circBase ID: hsa_circ_0090231
Name: hsa_circ_USP9X
Synonym: circ-USP9X
Host Gene: hsa-miR-599
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiovascular disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CLIC4
Associated microRNA: hsa-miR-599
Biological function: Inhibition of circ-USP9X elevated viability, promoted cell cycle progression and angiopoiesis, and decreased apoptosis, inflammation, and oxidative stress of ox-LDL-induced HUVEC.
Molecular mechanism: circ-USP9X regulated chloride intracellular channel 4 (CLIC4) messenger RNA expression by sponging microRNA (miR)-599.
Survival: -
Supported No.:
 1
Description:

In conclusion, circ-USP9X silencing decreased ox-LDL-induced endothelial cell injury via the miR-599/CLIC4 axis, which offered a novel molecular mechanism to comprehend the pathology of AS.
Other information
Title:

Circ-USP9X Inhibition Reduces Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury via the microRNA 599/Chloride Intracellular Channel 4 Axis.

Journal: J Cardiovasc Pharmacol
Published: 2021/7/17
PubMed ID: 34269702