circRNA basic information
circBase ID: hsa_circ_0080229
Name: hsa_circ_EGFR
Synonym: circ_0080229
Host Gene: hsa-miR-1827
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U87, U251
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM2
Associated microRNA: hsa-miR-1827
Biological function: -
Molecular mechanism: -
Survival: poor
Supported No.:
 2
Description:

the silencing of circ_0080229 upregulates the expression of miR-1827, which in turn resulted in the suppression of MDM2, and the mediation of the downstream P53 signaling pathway. Circ_0080229 exerted an effect in mediating tumor progression through the MDM2 signaling pathway by sponging miR-1827.

Other information
Title:

Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism.

Journal: Ann Transl Med
Published: 2021/7/17
PubMed ID: 34268375