circRNA basic information
circBase ID: -
Name: hsa_circ_ASXL1
Synonym: CircASXL1
Host Gene: hsa-miR-206
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF-1alpha
Associated microRNA: hsa-miR-206
Biological function: CircASXL1 knockdown reversed hypoxia-mediated promotion effects on DDP resistance, cell proliferation, migration, and invasion, and inhibition impact on cell apoptosis, whereas these effects were restored by miR-206 inhibitor.
Molecular mechanism: CircASXL1 silencing downregulated HIF-1alpha expression by controlling hsa-miR-206 expression
Survival: -
Supported No.:
 1
Description:

CircASXL1 knockdown inhibited DDP resistance, cell proliferation, migration and invasion, whereas induced cell apoptosis under hypoxia by associating with miR-206 in NSCLC.

Other information
Title:

CircASXL1 Knockdown Restrains Hypoxia-Induced DDP Resistance and NSCLC Progression by Sponging miR-206.

Journal: Cancer Manag Res
Published: 2021/7/9
PubMed ID: 34234552