circRNA basic information
circBase ID: hsa_circ_0000277
Name: hsa_circ_PDE3B
Synonym: circPDE3B
Host Gene: hsa-miR-4766-5p
 
 
 
Disease basic information
DO ID:
 1107
DO name: esophageal carcinoma
Disease details: esophageal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: LAMA1
Associated microRNA: hsa-miR-4766-5p
Biological function: circPDE3B promoted the tumorigenesis and metastasis
Molecular mechanism: circPDE3B-hsa-miR-4766-5p/LAMA1 axis
Survival: poor
Supported No.:
 1
Description:

the circPDE3B/miR-4766-5p/LAMA1 axis functions as an oncogenic factor in promoting ESCC cell proliferation, migration, and invasion by inducing EMT, implying its potential prognostic and therapeutic significance in ESCC.
Other information
Title:

Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression.

Journal: Cell Death Dis
Published: 2021/7/7
PubMed ID: 34226522