circRNA basic information
circBase ID: hsa_circ_0006988
Name: -
Synonym: Circ_0006988
Host Gene: hsa-miR-491-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAP3K3
Associated microRNA: hsa-miR-491-5p
Biological function: Circ_0006988 silencing restrained NSCLC cell proliferation, migration, invasion and angiogenesis, and induced apoptosis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_0006988 knockdown reduced xenograft tumor growth. ssCirc_0006988 contributed to the development of NSCLC by miR-491-5p/MAP3K3 axis.
Other information
Title:

Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.

Journal: Cell Cycle
Published: 2021/7/1
PubMed ID: 34189997