circRNA basic information
circBase ID: hsa_circ_0019230
Name: hsa_circ_PLCE1
Synonym: CircPLCE1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (W480, SW620, HCT116, HT29, RKO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SRSF2
Associated microRNA: -
Biological function: circPLCE1 knockdown suppressed CRC cell proliferation, migration and invasion and increased apoptosis
Molecular mechanism: circPLCE1 directly bound to the SRSF2 protein, repressing SRSF2-dependent PLCE1 pre-RNA splicing
Survival: poor
Supported No.:
 2
Description:

CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing.
Other information
Title:

CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing.

Journal: J Cell Mol Med
Published: 2021/6/27
PubMed ID: 34173324