circRNA basic information
circBase ID: hsa_circ_0001686
Name: -
Synonym: Circ_0001686
Host Gene: hsa-miR-411-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: PCa cell lines (CWR22RV1, LNCaP)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: SMAD3/TGFBR2
Associated microRNA: hsa-miR-411-5p
Biological function: circ_0001686 promoted cell proliferation, migration, and invasion
Molecular mechanism: circ_0001686 could reduce hsa-miR-411-5p, affecting the downstream target genes of SMAD3 and TGFBR2
Survival: -
Supported No.:
 1
Description:

Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells.
Other information
Title:

Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p.

Journal: World J Mens Health
Published: 2021/6/26
PubMed ID: 34169675