circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: CircHIPK3
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NUPR1/PI3K/AKT axis
Associated microRNA: hsa-miR-637
Biological function: overexpressed circHIPK3 can significantly promote EMT, proliferation, and invasion of OSCC cells and can inhibit cell apoptosis in vivo and in vitro
Molecular mechanism: CircHIPK3 upregulated the activation of NUPR1 and PI3K/AKT
Survival: poor
Supported No.:
 3
Description:

Functionally, overexpressed circHIPK3 can significantly promote EMT, proliferation, and invasion of OSCC cells and can inhibit cell apoptosis in vivo and in vitro. In addition, CircHIPK3 upregulated the activation of NUPR1 and PI3K/AKT.
Other information
Title:

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637.

Journal: Ann Transl Med
Published: 2021/6/25
PubMed ID: 34164494