circRNA basic information
circBase ID: hsa_circ_0000064
Name: -
Synonym: circ_0000064
Host Gene: hsa-miR-30c-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: SV-MES13 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Lmp7
Associated microRNA: hsa-miR-30c-5p
Biological function: Circ_0000064 was an importantly downstream effector of emodin function in HG-induced SV40-MES13 cells.
Molecular mechanism: circ_0000064 directly targeted miR-30c-5p, and circ_0000064 modulated_mp7_xpression through miR-30c-5p.
Survival: -
Supported No.:
 1
Description:

Our findings identified that emodin alleviated HG-induced oxidative stress, inflammation and ECM accumulation in SV40-MES13 cells at least partially by the regulation of the circ_0000064/miR-30c-5p/Lmp7_xis.
Other information
Title:

Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis.

Journal: J Recept Signal Transduct Res
Published: 2021/6/22
PubMed ID: 34151713