circRNA basic information
circBase ID: hsa_circ_0035292
Name: hsa_circ_TMOD3
Synonym: circTMOD3
Host Gene: hsa-miR-146b-3p
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: cell line
Sample type details: WI-38 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCR1
Associated microRNA: hsa-miR-146b-3p
Biological function: CircTMOD3 was resistant to RNase R and was mainly present in the cytoplasm. Silencing endogenous circTMOD3 alleviated WI-38 cell injury and inflammation triggered by LPS.
Molecular mechanism: circTMOD3 directly targeted miR-146b-3p, and CXCR1 was a direct and functional target of miR-146b-3p. CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation.
Survival: -
Supported No.:
 3
Description:

Our findings demonstrated the regulation of circTMOD3 in LPS-induced cell injury and inflammation at least partially via miR-146b-3p-independent modulation of CXCR1.
Other information
Title:

The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells.

Journal: Exp Lung Res
Published: 2021/6/22
PubMed ID: 34151690