circRNA basic information
circBase ID: hsa_circ_0075503
Name: -
Synonym: circ_0075503
Host Gene: hsa-miR-15a-5p
 
 
 
Disease basic information
DO ID:
 288
DO name: endometriosis of uterus
Disease details: endometriosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF12
Associated microRNA: hsa-miR-15a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0075503 could regulate KLF12 expression by sponging miR-15a-5p. Knockdown of circ_0075503 inhibited E2-induced enhancement of cell migration and invasion in eutopic ESCs by regulating miR-15a-5p/KLF12 axis, indicating a novel target for the treatment of endometriosis.
Other information
Title:

Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.

Journal: Mol Cell Biochem
Published: 2021/6/13
PubMed ID: 34117589