circRNA basic information
circBase ID: -
Name: hsa_circ_C16orf62
Synonym: CircC16orf62
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTK2/AKT
Associated microRNA: hsa-miR-138-5p
Biological function: the reduction of CircC16orf62 expression promotes the proliferation, invasion, and glycolysis of HCC
Molecular mechanism: CircC16orf62 functioned as a molecular sponge for hsa-miR-138-5p, and a competitive endogenous RNA for PTK2, promoting AKT/mTOR pathway activation
Survival: poor
Supported No.:
 1
Description:

CircC16orf62 functions as an oncogene in HCC progression, behaving as a competitive endogenous RNA for miR-138-5p binding, thus activating the AKT/mTOR pathway.
Other information
Title:

CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.

Journal: Cell Death Dis
Published: 2021/6/11
PubMed ID: 34108451