circRNA basic information
circBase ID: hsa_circ_0006168
Name: hsa_circ_CNOT6L
Synonym: -
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human oesophageal epithelial cells (HET-1A), ESCC cells (Eca109)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JMJD1C
Associated microRNA: hsa-miR-194-5p
Biological function: knockdown of circ_0006168 or JMJD1C increased Taxol sensitivity of ESCC in vitro via inhibiting cell proliferation, migration and invasion, and promoting apoptosis
Molecular mechanism: circ_0006168 could directly bind to hsa-miR-194-5p and JMJD1C was verified as a direct target of hsa-miR-194-5p
Survival: -
Supported No.:
 3
Description:

Circ_0006168 facilitated Taxol resistance in ESCC by regulating miR-194-5p/JMJD1C axis, providing a promising therapeutic target for ESCC chemotherapy.
Other information
Title:

Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis.

Journal: Cancer Cell Int
Published: 2021/5/24
PubMed ID: 34022910