circRNA basic information
circBase ID: -
Name: hsa_circ_LDB2
Synonym: circLDB2
Host Gene: hsa-miR-346
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-squamousnon-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A549, H23, H460 non-squamous NSCLC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: LIMCH1
Associated microRNA: hsa-miR-346
Biological function: Overexpression of circLDB2 impeded cell proliferation, migration, invasion, and enhanced apoptosis and cisplatin sensitivity in vitro, as well as promoted the antitumor effect of cisplatin in vivo
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 4
Description:

circLDB2 impeded non-squamous NSCLC development and enhanced cisplatin sensitivity partially by acting as a ceRNA, highlighting circLDB2 as a promising candidate for the development of novel antitumor therapies.
Other information
Title:

Circular RNA circLDB2 functions as a competing endogenous RNA to suppress development and promote cisplatin sensitivity in non-squamous non-small cell lung cancer.

Journal: Thorac Cancer
Published: 2021/6/8
PubMed ID: 34096174