circRNA basic information
circBase ID: -
Name: hsa_circ_MFN2
Synonym: Circ-MFN2
Host Gene: hsa-miR-574-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1R
Associated microRNA: hsa-miR-574-3p
Biological function: Knockdown of circ-MFN2 restrained the proliferation, migration, invasion, and radioresistance of CRC cells in vitro
Molecular mechanism: positively regulate IGF1R expression by sponging hsa-miR-574-3p
Survival: -
Supported No.:
 1
Description:

circ-MFN2 promoted the proliferation, metastasis and radioresistance of CRC through regulating the miR-574-3p/IGF1R axis, suggesting that circ-MFN2 might be a novel therapeutic biomarker for CRC.
Other information
Title:

Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis.

Journal: Front Genet
Published: 2021/6/8
PubMed ID: 34093664